5-HT5A receptor (5ht5a_human)

FAMILY

Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors 5-HT5A receptor

GENE

HTR5A

ORGANISM

Human (Homo sapiens)

ALT. NAMES

5-hydroxytryptamine receptor 5A, 5-HT-5, 5-HT-5A, 5-HT5A, Serotonin receptor 5A

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
D
L
P
V
N
L
T
S
F
10
                   
S
L
S
T
P
S
P
L
E
T
20
                   
N
H
S
L
G
K
D
D
L
R
30
          TM1    
P
S
S
P
L
L
S
V
F
G
40
                   
V
L
I
L
T
L
L
G
F
L
50
                   
V
A
A
T
F
A
W
N
L
L
60
                   
V
L
A
T
I
L
R
V
R
T
70
ICL1 TM2      
F
H
R
V
P
H
N
L
V
A
80
                   
S
M
A
V
S
D
V
L
V
A
90
                   
A
L
V
M
P
L
S
L
V
H
100
        ECL1    
E
L
S
G
R
R
W
Q
L
G
110
TM3              
R
R
L
C
Q
L
W
I
A
C
120
                   
D
V
L
C
C
T
A
S
I
W
130
                   
N
V
T
A
I
A
L
D
R
Y
140
          ICL2  
W
S
I
T
R
H
M
E
Y
T
150
TM4              
L
R
T
R
K
C
V
S
N
V
160
                   
M
I
A
L
T
W
A
L
S
A
170
                   
V
I
S
L
A
P
L
L
F
G
180
ECL2            
W
G
E
T
Y
S
E
G
S
E
190
            TM5  
E
C
Q
V
S
R
E
P
S
Y
200
                   
A
V
F
S
T
V
G
A
F
Y
210
                   
L
P
L
C
V
V
L
F
V
Y
220
                   
W
K
I
Y
K
A
A
K
F
R
230
                   
V
G
S
R
K
T
N
S
V
S
240
ICL3            
P
I
S
E
A
V
E
V
K
D
250
                   
S
A
K
Q
P
Q
M
V
F
T
260
                   
V
R
H
A
T
V
T
F
Q
P
270
      TM6        
E
G
D
T
W
R
E
Q
K
E
280
                   
Q
R
A
A
L
M
V
G
I
L
290
                   
I
G
V
F
V
L
C
W
I
P
300
                   
F
F
L
T
E
L
I
S
P
L
310
  ECL3 TM7    
C
S
C
D
I
P
A
I
W
K
320
                   
S
I
F
L
W
L
G
Y
S
N
330
                   
S
F
F
N
P
L
I
Y
T
A
340
  H8              
F
N
K
N
Y
N
S
A
F
K
350
      C-term
N
F
F
S
R
Q
H

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 R T F H ICL1ECL1 R R W Q L ECL1ICL2 H M E Y T ICL2ECL2 W G E T Y S E G S E E C Q V S R ECL2ICL3 V S P I S E A V E V K D S A K Q P Q M V F T V R H A T V T F Q P E G D ICL3ECL3 S C D I ECL3N-term M D L P V N L T S F S L S T P S P L E T N H S L G K D D L R P S S P L N-termC-term S R Q H C-term L S V F G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V G S R K T N S T W R E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N F K N Y N S A F F
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N W A F T A A V L F G L L T L I L V G 1 A S M A V S D V L V A L A V M P L S L V H 2 A T V N W I S A T C C L V D C A I W L Q 3 S N V M I A L T W A L S A V I S L A P L 4 Y V F L V V C L P L Y F A G V T S F V A Y 5 G I L I G V F V L C W I P F F L T E L I 6 L P N F F S N S Y G L W L F I S K W I 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

164 mutation data points available.

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine

STRUCTURE MODELS

5ht5a_human active,

5ht5a_human inactive

STRUCTURES

Found 5 structure(s) - view all details on the Structures page

PDBs: 7UM4, 7UM5, 7UM6, 7UM7, 7X5H